Joe Mixon’s 2025 season is in limbo. The Texans placed him on the non-football injury list and he has not practiced since mid‑July, with no clear return date. In his absence, Houston has leaned on Nick Chubb, while Dare Ogunbowale, Dameon Pierce and rookie Woody Marks handle depth duties. For fantasy managers, hold Mixon in IR spots if possible, but be prepared to pivot in shallow leagues as a late-season return remains uncertain.

Joe Mixon’s 2025 season is in serious doubt after landing on the NFI-reserve list with a foot injury, leaving Houston’s backfield in flux. Week 2 pivots to Nick Chubb as the primary early-down option, with Dameon Pierce and Woody Marks providing depth behind him. For fantasy managers, Mixon’s absence means a quick roster reallocation and a shift toward safer Week 2 plays.

Owners should stash Mixon only in IR spots; otherwise, plan as if he won’t return soon. Chubb becomes the immediate focal point for Houston’s rushing attack, and the rest of the committee may carve out belt-Toyota touches. Monitor timelines and adjust lineups accordingly as updates come in.